SSPLAXExample
Resilience check
Biomanufacturing Scale-Up
Biologics manufacturing: upstream bioreactors (fed-batch or perfusion) → purification → fill/finish → released product. Fed-batch is cheaper per batch. Perfusion has higher productivity but more cost.
Decision logic
Stress a baseline operating plan, see what output survives, and identify the fastest recovery move.
Decision question
If purification slips 20%, what output survives and which recovery move matters first?
Model output
Released product after shock40 kg/month
Fastest recovery moveRestore ~10% purification capacity
Budget headroom~$1.08M/month
Active limits
- Purification at capacity
- Fed-batch also saturated
Key insight
A downstream loss turns a balanced line into a recovery problem, and modest purification relief restores output faster than spending elsewhere.
The line becomes recovery-limited once purification drops below baseline.
Upstream keeps producing, but released output no longer follows it.
Restoring even 10% of purification capacity recovers ~4 kg/month of output.